Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships-Reference-Cited by-同舟云学术

Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships

Published:2008-01-18 Issue:3 Volume:51 Page:487-501
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Vanotti Ermes¹,Amici Raffaella¹,Bargiotti Alberto¹,Berthelsen Jens¹,Bosotti Roberta¹,Ciavolella Antonella¹,Cirla Alessandra¹,Cristiani Cinzia¹,D’Alessio Roberto¹,Forte Barbara¹,Isacchi Antonella¹,Martina Katia¹,Menichincheri Maria¹,Molinari Antonio¹,Montagnoli Alessia¹,Orsini Paolo¹,Pillan Antonio¹,Roletto Fulvia¹,Scolaro Alessandra¹,Tibolla Marcellino¹,Valsasina Barbara¹,Varasi Mario¹,Volpi Daniele¹,Santocanale Corrado¹

Affiliation:

1. Nerviano Medical Sciences Srl, Viale Pasteur 10, 20014 Nerviano, Milano, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm700956r

Reference26 articles.

1. Chabner, B. A., Ryan, D. P., Paz-Arez, L., Garcia-Carbonero, R., and Calabresi, P.The Pharmacological basis of therapeutics;McGraw-Hill:New York, 2001; Chapter 52, pp1389–1460.

2. Molecular mechanisms of drug resistance

3. DNA Replication in Eukaryotic Cells

4. Identification of Mcm2 Phosphorylation Sites by S-phase-regulating Kinases

5. Cdc7-Dbf4 Phosphorylates MCM Proteins via a Docking Site-Mediated Mechanism to Promote S Phase Progression

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