1. Department of Structural Biology and Bioinformatics, Faculty of Medicine & Pharmacy Section, Faculty of Sciences, Geneva University, Geneva, Switzerland, Laboratory Medicine Service, Department of Genetic & Laboratory Medicine, Geneva University Hospital, CH-1211 Geneva 14, Switzerland, CEA-DSV-iRTSV/BBSI, CEA Grenoble, 17 rue des martyrs, F-38054 Grenoble Cedex 9, France, and CNRS UMR 5092, 17 rue des martyrs, F-38054 Grenoble Cedex 9, France