Are the Duocarmycin and CC-1065 DNA Alkylation Reactions Acid-Catalyzed? Solvolysis pH−Rate Profiles Suggest They Are Not-Reference-Cited by-同舟云学术

Are the Duocarmycin and CC-1065 DNA Alkylation Reactions Acid-Catalyzed? Solvolysis pH−Rate Profiles Suggest They Are Not

Published:1999-07-01 Issue:15 Volume:64 Page:5666-5669
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Boger Dale L.¹,Garbaccio Robert M.¹

Affiliation:

1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo990762g

Reference30 articles.

1. CC-1065 and the Duocarmycins: Understanding their Biological Function through Mechanistic Studies

2. Sequence selectivity of DNA covalent modification

3. Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065

4. Acid-Dependent Electrophilicity of Cyclopropylpyrroloindoles. Nature's Masking Strategy for a Potent DNA Alkylator

5. Enzyme-like Rate Acceleration in the DNA Minor Groove. Cyclopropylpyrroloindoles as Mechanism-Based Inactivators of DNA

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