Liver-Selective Glucocorticoid Antagonists: A Novel Treatment for Type 2 Diabetes-Reference-Cited by-同舟云学术

Liver-Selective Glucocorticoid Antagonists: A Novel Treatment for Type 2 Diabetes

Published:2004-07-13 Issue:17 Volume:47 Page:4213-4230
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

von Geldern Thomas W.¹,Tu Noah¹,Kym Philip R.¹,Link James T.¹,Jae Hwan-Soo¹,Lai Chunqiu¹,Apelqvist Theresa¹,Rhonnstad Patrik¹,Hagberg Lars¹,Koehler Konrad¹,Grynfarb Marlena¹,Goos-Nilsson Annika¹,Sandberg Johnny¹,Österlund Marie¹,Barkhem Tomas¹,Höglund Marie¹,Wang Jiahong¹,Fung Steven¹,Wilcox Denise¹,Nguyen Phong¹,Jakob Clarissa¹,Hutchins Charles¹,Färnegårdh Mathias¹,Kauppi Björn¹,Öhman Lars¹,Jacobson Peer B.¹

Affiliation:

1. Metabolic Disease Research and Structural Biology Departments, Global Pharmaceutical Discovery, Abbott Laboratories, Abbott Park, Illinois 60064, and KaroBio AB, Huddinge, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0400045

Reference30 articles.

1. Disorders of gluconeogenesis

2. Hypoglycemia and lactic acidosis associated with fructose-1,6-diphosphatase deficiency

3. Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription and Hyperglycemia Are Regulated by Glucocorticoids in Genetically Obesedb/db Transgenic Mice

4. Successful Treatment of Cushing’s Syndrome with the Glucocorticoid Antagonist RU 486*

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