Improved P1/P1‘ Substituents for Cyclic Urea Based HIV-1 Protease Inhibitors: Synthesis, Structure−Activity Relationship, and X-ray Crystal Structure Analysis-Reference-Cited by-同舟云学术

Improved P1/P1‘ Substituents for Cyclic Urea Based HIV-1 Protease Inhibitors: Synthesis, Structure−Activity Relationship, and X-ray Crystal Structure Analysis

Published:1997-05-01 Issue:10 Volume:40 Page:1465-1474
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nugiel David A.¹,Jacobs Kim¹,Cornelius Lyndon¹,Chang Chong-Hwan¹,Jadhav Prabhakar K.¹,Holler Edward R.¹,Klabe Ronald M.¹,Bacheler Lee T.¹,Cordova Beverly¹,Garber Sena¹,Reid Carol¹,Logue Kelly A.¹,Gorey-Feret Lorraine J.¹,Lam Gilbert N.¹,Erickson-Viitanen Susan¹,Seitz Steven P.¹

Affiliation:

1. The DuPont Merck Pharmaceutical Company, P.O. Box 80500, Wilmington, Delaware 19880-0500

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm960839i

Reference27 articles.

1. L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor

2. ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.

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