Optimization of Naphthalimide-imidazoacridone with Potent Antitumor Activity Leading to Clinical Candidate (HKH40A, RTA 502)-Reference-Cited by-同舟云学术

Optimization of Naphthalimide-imidazoacridone with Potent Antitumor Activity Leading to Clinical Candidate (HKH40A, RTA 502)

Published:2007-10-16 Issue:23 Volume:50 Page:5557-5560
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hariprakasha Humcha K.¹,Kosakowska-Cholody Teresa¹,Meyer Colin¹,Cholody Wieslaw M.¹,Stinson Sherman F.¹,Tarasova Nadya I.¹,Michejda Christopher. J.¹

Affiliation:

1. Molecular Aspects of Drug Design Section, Structural Biophysics Laboratory, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702, Developmental Therapeutics Program, NCI-Frederick, Frederick Maryland 21702, and Reata Pharmaceuticals, 2801 Gateway Drive, Suite 150, Irving, Texas

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm7009777

Reference9 articles.

1. Why is cancer drug discovery so difficult?

2. The Consensus Coding Sequences of Human Breast and Colorectal Cancers

3. Bisimidazoacridones and Related Compounds: New Antineoplastic Agents with High Selectivity against Colon Tumors

4. Bisimidazoacridones induce a potent cytostatic effect in colon tumor cells that sensitizes them to killing by UCN-01

5. WMC-79, a potent agent against colon cancers, induces apoptosis through a p53-dependent pathway

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