A Single-Site Mutation (F429H) Converts the Enzyme CYP 2B4 into a Heme Oxygenase: A QM/MM Study-Reference-Cited by-同舟云学术

A Single-Site Mutation (F429H) Converts the Enzyme CYP 2B4 into a Heme Oxygenase: A QM/MM Study

Published:2012-02-22 Issue:9 Volume:134 Page:4053-4056
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Usharani Dandamudi¹,Zazza Costantino²,Lai Wenzhen¹,Chourasia Mukesh¹,Waskell Lucy³,Shaik Sason¹

Affiliation:

1. Institute of Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel

2. Scuola Normale Superiore di Pisa, Piazza dei Cavalieri 7, 56126 Pisa, Italy

3. University of Michigan and VA Medical Research Center, 2215 Fuller Road, Ann Arbor, Michigan 48105, United States

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja211905e

Reference39 articles.

1. P450 Enzymes: Their Structure, Reactivity, and Selectivity—Modeled by QM/MM Calculations

2. Autocatalytic Radical Reactions in Physiological Prosthetic Heme Modification

3. Structure and catalytic mechanism of heme oxygenase

4. Heme Oxygenase Reveals Its Strategy for Catalyzing Three Successive Oxygenation Reactions

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