Naphthyl and Coumarinyl Biarylpiperazine Derivatives as Highly Potent Human β-Secretase Inhibitors. Design, Synthesis, and Enzymatic BACE-1 and Cell Assays-Reference-Cited by-同舟云学术

Naphthyl and Coumarinyl Biarylpiperazine Derivatives as Highly Potent Human β-Secretase Inhibitors. Design, Synthesis, and Enzymatic BACE-1 and Cell Assays

Published:2006-06-10 Issue:14 Volume:49 Page:4275-4285
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Garino Cédrik¹,Tomita Taisuke¹,Pietrancosta Nicolas¹,Laras Younes¹,Rosas Roselyne¹,Herbette Gaëtan¹,Maigret Bernard¹,Quéléver Gilles¹,Iwatsubo Takeshi¹,Kraus Jean-Louis¹

Affiliation:

1. INSERM U-623, IBDM, Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Université de la Méditerranée, 13288 Marseille Cedex 9, France, Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Spectropole, Faculté Sciences de St Jérôme Avenue Escadrille Normandie Niémen, Université Paul Cézanne 13397 Marseille Cedex 20, France, and UMR 7565, Structure et Réactivité des Systèmes...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0602864

Reference33 articles.

1. Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

Cited by 57 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pathogenesis of Alzheimer’s Disease and Diversity of 1,2,3-Triazole Scaffold in Drug Development: Design Strategies, Structural Insights, and Therapeutic Potential;ACS Chemical Neuroscience;2023-09-08

2. A Review on the Arylpiperazine Derivatives as Potential Therapeutics for the Treatment of Various Neurological Disorders;Current Drug Targets;2022-07

3. Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1;Journal of Medicinal Chemistry;2021-02-23

4. Semi-synthesis of C28-modified triterpene acid derivatives from maslinic acid or corosolic acid as potential α-glucosidase inhibitors;Bioorganic Chemistry;2020-04

5. Novel small molecule therapeutic agents for Alzheimer disease: Focusing on BACE1 and multi-target directed ligands;Bioorganic Chemistry;2020-04