Virtual Screening and Computational Optimization for the Discovery of Covalent Prolyl Oligopeptidase Inhibitors with Activity in Human Cells-Reference-Cited by-同舟云学术

Virtual Screening and Computational Optimization for the Discovery of Covalent Prolyl Oligopeptidase Inhibitors with Activity in Human Cells

Published:2012-07-17 Issue:14 Volume:55 Page:6306-6315
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

De Cesco Stéphane¹,Deslandes Sébastien¹,Therrien Eric¹,Levan David¹,Cueto Mickaël¹,Schmidt Ralf²,Cantin Louis-David²,Mittermaier Anthony¹,Juillerat-Jeanneret Lucienne³,Moitessier Nicolas¹

Affiliation:

1. Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, Québec H3A 0B8, Canada

2. AstraZeneca R&D Montréal, 7171 Frédérick-Banting, St. Laurent, Québec H4S 1Z9, Canada

3. University Institute of Pathology, CHUV-UNIL, Rue du Bugnon 25, CH-1011, Lausanne, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3002839

Reference44 articles.

1. Concerted Structural Changes in the Peptidase and the Propeller Domains of Prolyl Oligopeptidase are Required for Substrate Binding

2. Unusual secondary specificity of prolyl oligopeptidase and the different reactivities of its two forms toward charged substrates

3. Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells

4. Distribution of prolyl endopeptidase activities in rat and human brain

5. Structure, Function and Biological Relevance of Prolyl Oligopeptidase

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