Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Antitumor Activity in Cancer Cells That Display Resistance to Proapoptotic Stimuli: An Investigation of Structure−Activity Relationship and Mechanistic Insight-Reference-Cited by-同舟云学术

Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Antitumor Activity in Cancer Cells That Display Resistance to Proapoptotic Stimuli: An Investigation of Structure−Activity Relationship and Mechanistic Insight

Published:2009-09-29 Issue:20 Volume:52 Page:6244-6256
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lamoral-Theys Delphine¹,Andolfi Anna²,Van Goietsenoven Gwendoline³,Cimmino Alessio²,Le Calvé Benjamin³,Wauthoz Nathalie⁴,Mégalizzi Véronique³,Gras Thierry³,Bruyère Céline³,Dubois Jacques¹,Mathieu Véronique³,Kornienko Alexander⁵,Kiss Robert³,Evidente Antonio²

Affiliation:

1. Laboratoire de Chimie Analytique, Toxicologie et Chimie Physique Appliquée

2. Dipartimento di Scienze del Suolo, della Pianta, dell’Ambiente e delle Produzioni Animali, Università di Napoli Federico II, Via Università 100, 80055 Portici, Italy

3. Laboratoire de Toxicologie

4. Laboratoire de Pharmacie Galénique et Biopharmacie

5. Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, New Mexico 87801

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901031h

Reference60 articles.

1. Lycorine as an inhibitor of ascorbic acid biosynthesis

2. Lycorine: A powerful inhibitor of L-galactono-γ-lactone dehydrogenase activity