1. Faculty of Pharmaceutical Sciences and School of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan, Department of Biochemistry, Saitama University, Urawa, Saitama 338-0825, Japan, and National Institute of Bioscience and Human Technology, 1-1, Higashi, Tsukuba, Ibaraki 305-8566, Japan