Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin-Reference-Cited by-同舟云学术

Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin

Published:2013-11-19 Issue:23 Volume:56 Page:9542-9555
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Spicer Julie A.¹²,Lena Gersande¹,Lyons Dani M.¹,Huttunen Kristiina M.¹³,Miller Christian K.¹,O’Connor Patrick D.¹,Bull Matthew¹²,Helsby Nuala¹²,Jamieson Stephen M. F.¹²,Denny William A.¹²,Ciccone Annette⁴,Browne Kylie A.⁴,Lopez Jamie A.⁴,Rudd-Schmidt Jesse⁴,Voskoboinik Ilia⁴,Trapani Joseph A.⁴⁵

Affiliation:

1. Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

2. Maurice Wilkins Centre for Molecular Biodiscovery, A New Zealand Centre for Research Excellence, Auckland, New Zealand

3. School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland

4. Cancer Immunology Program, Peter MacCallum Cancer Centre, St. Andrew’s Place, East Melbourne, Victoria 3002, Australia

5. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3052 Australia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401604x

Reference45 articles.

1. Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death

2. Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules

3. The battlefield of perforin/granzyme cell death pathways

4. Structure and function of human perforin

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