Use of Density Functional Calculations To Predict the Regioselectivity of Drugs and Molecules Metabolized by Aldehyde Oxidase-Reference-Cited by-同舟云学术

Use of Density Functional Calculations To Predict the Regioselectivity of Drugs and Molecules Metabolized by Aldehyde Oxidase

Published:2007-08-25 Issue:19 Volume:50 Page:4642-4647
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Torres Rhonda A.¹,Korzekwa Kenneth R.¹,McMasters Daniel R.¹,Fandozzi Christine M.¹,Jones Jeffrey P.¹

Affiliation:

1. Department of Molecular Systems, Merck Research Laboratories, Rahway, New Jersey 07065, Department of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19468, and Department of Chemistry, Washington State University, Pullman, Washington 99164

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0703690

Reference32 articles.

1. Human Liver Aldehyde Oxidase: Inhibition by 239 Drugs

2. Drugs That Inhibit Oxidation Reactions Catalyzed by Aldehyde Oxidase Do Not Inhibit the Reductive Metabolism of Ziprasidone to its Major Metabolite, S-Methyldihydroziprasidone

3. POTENT INHIBITION OF HUMAN LIVER ALDEHYDE OXIDASE BY RALOXIFENE

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