Scale-Up of a Vilsmeier Formylation Reaction: Use of HEL Auto-MATE and Simulation Techniques for Rapid and Safe Transfer to Pilot Plant from Laboratory-Reference-Cited by-同舟云学术

Scale-Up of a Vilsmeier Formylation Reaction: Use of HEL Auto-MATE and Simulation Techniques for Rapid and Safe Transfer to Pilot Plant from Laboratory

Published:2002-04-24 Issue:3 Volume:6 Page:311-316
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Dyer Ulrich C.¹,Henderson David A.¹,Mitchell Mark B.¹,Tiffin Peter D.¹

Affiliation:

1. Chemical Synthesis Department, Roche Discovery Welwyn, Broadwater Road, Welwyn Garden City, Hertfordshire, AL7 3AY, UK

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op0155211

Reference5 articles.

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2. Nuclear magnetic resonance investigations of carbonium ion intermediates. Part III. A chlorine-35 quadrupole resonance study of several (R-chloromethylene)dimethylammonium salts (Vilsmeier–Haack and Viehe reagents)

3. The mechanism of the Vilsmeier–Haack reaction. Part II. A kinetic study of the formylation of thiophen derivatives with dimethylformamide and phosphorus oxychloride or carbonyl chloride in 1,2-dichloroethane

4. Rapid Process Development and Scale-Up Using A Multiple Reactor System

5. Bollyn, M.; Van den Bergh, A.; Wright, A.Chem.AnlagenVerfahren1996,29, 95.

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