Discovery of N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a Novel Clinical AMPA Receptor Positive Modulator-Reference-Cited by-同舟云学术

Discovery of N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a Novel Clinical AMPA Receptor Positive Modulator

Published:2010-07-08 Issue:15 Volume:53 Page:5801-5812
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ward Simon E.¹,Harries Mark¹,Aldegheri Laura²,Andreotti Daniele²,Ballantine Stuart³,Bax Benjamin D.³,Harris Andrew J.¹,Harker Andy J.¹,Lund Jesper²,Melarange Rosemary¹,Mingardi Anna²,Mookherjee Claudette¹,Mosley Julie³,Neve Marta²,Oliosi Beatrice²,Profeta Roberto²,Smith Kathrine J.³,Smith Paul W.¹,Spada Simone²,Thewlis Kevin M.¹,Yusaf Shahnaz P.³

Affiliation:

1. Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, United Kingdom

2. Centro Ricerche, GlaxoSmithKline, Via A. Fleming 4, 37100 Verona, Italy

3. Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1005429

Reference36 articles.

1. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

2. The Role of AMPA receptor modulation in the treatment of neuropsychiatric diseases

3. Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data