Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone-Reference-Cited by-同舟云学术

Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone

Published:2009-07-17 Issue:15 Volume:52 Page:4794-4809
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Brough Paul A.¹,Barril Xavier¹,Borgognoni Jenifer¹,Chene Patrick²,Davies Nicholas G. M.¹,Davis Ben¹,Drysdale Martin J.¹,Dymock Brian¹,Eccles Suzanne A.³,Garcia-Echeverria Carlos²,Fromont Christophe¹,Hayes Angela³,Hubbard Roderick E.¹,Jordan Allan M.¹,Jensen Michael Rugaard²,Massey Andrew¹,Merrett Angela¹,Padfield Antony¹,Parsons Rachel¹,Radimerski Thomas²,Raynaud Florence I.³,Robertson Alan¹,Roughley Stephen D.¹,Schoepfer Joseph²,Simmonite Heather¹,Sharp Swee Y.³,Surgenor Allan¹,Valenti Melanie³,Walls Steven¹,Webb Paul¹,Wood Mike¹,Workman Paul³,Wright Lisa¹

Affiliation:

1. Vernalis Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, U.K.

2. Novartis Institutes for Biomedical Research, Novartis Pharma AG, CH-4002 Basel, Switzerland

3. Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey SM2 5NG, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900357y

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1. Molecular chaperones and the stress of oncogenesis