Design of Potent Inhibitors of Human RAD51 Recombinase Based on BRC Motifs of BRCA2 Protein: Modeling and Experimental Validation of a Chimera Peptide-Reference-Cited by-同舟云学术

Design of Potent Inhibitors of Human RAD51 Recombinase Based on BRC Motifs of BRCA2 Protein: Modeling and Experimental Validation of a Chimera Peptide

Published:2010-07-12 Issue:15 Volume:53 Page:5782-5791
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nomme Julian¹,Renodon-Cornière Axelle¹,Asanomi Yuya²,Sakaguchi Kazuyasu²,Stasiak Alicja Z.³,Stasiak Andrzej³,Norden Bengt⁴,Tran Vinh¹,Takahashi Masayuki¹

Affiliation:

1. UMR 6204 U-3B, Centre National de la Recherche Scientifique & Université de Nantes, F-44322 Nantes cedex 3, France

2. Department of Chemistry, Faculty of Science, Hokkaido University, 060-0810 Sapporo, Japan

3. Centre Intégratif de Génomique, Faculté de Biologie et de Médecine, Université de Lausanne, CH-1015 Lausanne-Dorigny, Switzerland

4. Department of Chemistry and Bioscience, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1002974

Reference37 articles.

1. Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes.

2. Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

3. Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation

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