Identification of (R)-1-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a Potent TRPV1 Antagonist for Pain Management-Reference-Cited by-同舟云学术

Identification of (R)-1-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a Potent TRPV1 Antagonist for Pain Management

Published:2008-01-10 Issue:3 Volume:51 Page:392-395
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gomtsyan Arthur¹,Bayburt Erol K.¹,Schmidt Robert G.¹,Surowy Carol S.¹,Honore Prisca¹,Marsh Kennan C.¹,Hannick Steven M.¹,McDonald Heath A.¹,Wetter Jill M.¹,Sullivan James P.¹,Jarvis Michael F.¹,Faltynek Connie R.¹,Lee Chih-Hung¹

Affiliation:

1. Global Pharmaceutical Research and Development, Neuroscience Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm701007g

Reference22 articles.

1. Transient Receptor Potential Cation Channels in Disease

2. The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

3. The capsaicin receptor: a heat-activated ion channel in the pain pathway

4. The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway

5. Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function

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