Synthesis of a Series of Stromelysin-Selective Thiadiazole Urea Matrix Metalloproteinase Inhibitors

Author:

Jacobsen E. Jon1,Mitchell Mark A.1,Hendges Susan K.1,Belonga Kenneth L.1,Skaletzky Louis L.1,Stelzer Lindsay S.1,Lindberg Thomas. J.1,Fritzen Edward L.1,Schostarez Heinrich J.1,O'Sullivan Theresa J.1,Maggiora Linda L.1,Stuchly Christopher W.1,Laborde Alice L.1,Kubicek Marc F.1,Poorman Roger A.1,Beck Joan M.1,Miller Henry R.1,Petzold Gary L.1,Scott Pam S.1,Truesdell Scott E.1,Wallace Tanya L.1,Wilks John W.1,Fisher Christopher1,Goodman Linda V.1,Kaytes Paul S.1,Ledbetter Stephen R.1,Powers Elaine A.1,Vogeli Gabriel1,Mott John E.1,Trepod Catherine M.1,Staples Douglas J.1,Baldwin Eric T.1,Finzel Barry C.1

Affiliation:

1. Departments of Structural, Analytical and Medicinal Chemistry, Protein Science, Genomics, Discovery Technologies, Cell and Molecular Biology, and Chemical Process Research & Preparations, Pharmacia & Upjohn, Kalamazoo, Michigan 49007

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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