Major Groove Binding and ‘DNA-Induced' Fit in the Intercalation of a Derivative of the Mixed Topoisomerase I/II Poison N-(2-(Dimethylamino)ethyl)acridine-4- carboxamide (DACA) into DNA: X-ray Structure Complexed to d(CG(5-BrU)ACG)2 at 1.3-Å Resolution-Reference-Cited by-同舟云学术

Major Groove Binding and ‘DNA-Induced' Fit in the Intercalation of a Derivative of the Mixed Topoisomerase I/II Poison N-(2-(Dimethylamino)ethyl)acridine-4- carboxamide (DACA) into DNA: X-ray Structure Complexed to d(CG(5-BrU)ACG)2 at 1.3-Å Resolution

Published:1999-02-01 Issue:4 Volume:42 Page:536-540
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Todd Alan K.¹,Adams Adrienne¹,Thorpe James H.¹,Denny William A.¹,Wakelin Laurence P. G.¹,Cardin Christine J.¹

Affiliation:

1. Chemistry Department, University of Reading, Whiteknights, Reading RG6 6AD, U.K., Biochemistry Department, Trinity College, Dublin 2, Ireland, Auckland Cancer Society Research Centre, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand, and Chemistry Department, University College Dublin, Belfield, Dublin 4, Ireland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980479u

Reference25 articles.

1. DNA topoisomerase targeting drugs: mechanisms of action and perspectives

2. Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

3. A Model for the Mechanism of Human Topoisomerase I

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