Alkynylpyrimidine Amide Derivatives as Potent, Selective, and Orally Active Inhibitors of Tie-2 Kinase-Reference-Cited by-同舟云学术

Alkynylpyrimidine Amide Derivatives as Potent, Selective, and Orally Active Inhibitors of Tie-2 Kinase

Published:2007-01-25 Issue:4 Volume:50 Page:627-640
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cee Victor J.¹,Albrecht Brian K.¹,Geuns-Meyer Stephanie¹,Hughes Paul¹,Bellon Steve¹,Bready James¹,Caenepeel Sean¹,Chaffee Stuart C.¹,Coxon Angela¹,Emery Maurice¹,Fretland Jenne¹,Gallant Paul¹,Gu Yan¹,Hodous Brian L.¹,Hoffman Doug¹,Johnson Rebecca E.¹,Kendall Richard¹,Kim Joseph L.¹,Long Alexander M.¹,McGowan David¹,Morrison Michael¹,Olivieri Philip R.¹,Patel Vinod F.¹,Polverino Anthony¹,Powers David¹,Rose Paul¹,Wang Ling¹,Zhao Huilin¹

Affiliation:

1. Departments of Medicinal Chemistry, Molecular Pharmacology, and Molecular Structure, Amgen Inc., One Kendall Square, Bldg. 1000, Cambridge, Massachusetts 02139; Departments of Molecular Pharmacology, Oncology Research, Pharmaceutics, and Pharmacokinetics and Drug Metabolism, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm061112p

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