Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies-Reference-Cited by-同舟云学术

Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies

Published:2013-06-04 Issue:11 Volume:56 Page:4465-4481
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Taylor Steven J.,Padyana Anil K.,Abeywardane Asitha,Liang Shuang,Hao Ming-Hong¹,De Lombaert Stéphane²,Proudfoot John,Farmer Bennett S.,Li Xiang,Collins Brandon,Martin Leslie,Albaugh Daniel R.,Hill-Drzewi Melissa³,Pullen Steven S.,Takahashi Hidenori

Affiliation:

1. H3 Biomedicine, 300 Technology Square, Cambridge, Massachusetts 02139, United States

2. Karos Pharmaceuticals, 5 Science Park, 401 Winchester Avenue, New Haven, Connecticut 06511, United States

3. Lead Evaluation Department, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm400138z

Reference49 articles.

1. Mast cells: an expanding pathophysiological role from allergy to other disorders

2. Mast cells in atherosclerosis

3. Purification and characterization of angiotensin II-generating chymase from hamster cheek pouch

4. Chymase-Dependent Angiotensin II Formation in Human Vascular Tissue

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