Potent, Selective and Low-Calcemic Inhibitors of CYP24 Hydroxylase:  24-Sulfoximine Analogues of the Hormone 1α,25-Dihydroxyvitamin D3

Author:

Kahraman Mehmet1,Sinishtaj Sandra1,Dolan Patrick M.1,Kensler Thomas W.1,Peleg Sara1,Saha Uttam1,Chuang Samuel S.1,Bernstein Galina1,Korczak Bozena1,Posner Gary H.1

Affiliation:

1. Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, Division of Toxicological Sciences, Department of Environmental Health Sciences, Bloomberg School of Hygiene, The Johns Hopkins University, Baltimore, Maryland 21205, Department of Medical Specialities, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030, and Cytochroma, Inc., Markham, Ontario, Canada L3R 8E4

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference32 articles.

1. Holick, M. F.Vitamin D:  Molecular Biology, Physiology, and ClinicalApplications; Humana Press:  Totowa, NJ, 1999.

2. Feldman, D.; Glorieux, F.; Pike, J. W.Vitamin D; Academic Press:  San Diego, CA, 1997.

3. Conceptually New 20-epi-22-Oxa Sulfone Analogues of the Hormone 1α,25-Dihydroxyvitamin D3:  Synthesis and Biological Evaluation

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