1. Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center (UNMC), Omaha, Nebraska 68198-5830, Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center and Saint Louis School of Medicine, Department of Internal Medicine, Division of Geriatrics, St. Louis, Missouri 63106, and Faculty of Chemistry, M.V. Lomonosov Moscow State University, 119899 Moscow, Russia