Structure-Based Design and Synthesis of Lipophilic 2,4-Diamino-6-Substituted Quinazolines and Their Evaluation as Inhibitors of Dihydrofolate Reductases and Potential Antitumor Agents-Reference-Cited by-同舟云学术

Structure-Based Design and Synthesis of Lipophilic 2,4-Diamino-6-Substituted Quinazolines and Their Evaluation as Inhibitors of Dihydrofolate Reductases and Potential Antitumor Agents

Published:1998-08-01 Issue:18 Volume:41 Page:3426-3434
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gangjee Aleem¹,Vidwans Anup P.¹,Vasudevan Anil¹,Queener Sherry F.¹,Kisliuk Roy L.¹,Cody Vivian¹,Li Ruming¹,Galitsky Nikolai¹,Luft Joe R.¹,Pangborn Walter¹

Affiliation:

1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, Indiana 46202, Department of Biochemistry, School of Medicine, Tufts University, Boston, Massachusetts 02111, and Hauptman-Woodward Medical Research Institute Inc., 73 High Street, Buffalo, New York 14203

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980081y

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5. Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent.

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