Synthesis of a Muscarinic Receptor Antagonist via a Diastereoselective Michael Reaction, Selective Deoxyfluorination and Aromatic Metal−Halogen Exchange Reaction-Reference-Cited by-同舟云学术

Synthesis of a Muscarinic Receptor Antagonist via a Diastereoselective Michael Reaction, Selective Deoxyfluorination and Aromatic Metal−Halogen Exchange Reaction

Published:2001-09-07 Issue:20 Volume:66 Page:6775-6786
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Mase Toshiaki¹,Houpis Ioannis N.¹,Akao Atsushi¹,Dorziotis Ilias¹,Emerson Khateeta¹,Hoang Thoa¹,Iida Takehiko¹,Itoh Takahiro¹,Kamei Keisuke¹,Kato Shinji¹,Kato Yoshiaki¹,Kawasaki Masashi¹,Lang Fengrui¹,Lee Jaemoon¹,Lynch Joseph¹,Maligres Peter¹,Molina Audrey¹,Nemoto Takayuki¹,Okada Shigemitsu¹,Reamer Robert¹,Song Jake Z.¹,Tschaen David¹,Wada Toshihiro¹,Zewge Daniel¹,Volante R. P.¹,Reider Paul J.¹,Tomimoto Koji¹

Affiliation:

1. Process R & D, Laboratories for Technology Development, Banyu Pharmaceutical Co. Ltd., Kamimutsuna 3-Chome-9-1, Okazaki, Aichi 444-0858, Japan, and Merck Research Laboratories, Department of Process Chemistry, P.O. Box 2000, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo0157425

Reference79 articles.

1. Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

2. Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence

3. Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

4. Identification of a Family of Muscarinic Acetylcholine Receptor Genes

5. Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

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