Incorporation of Piperazino Functionality into 1,3-Disubstituted Urea as the Tertiary Pharmacophore Affording Potent Inhibitors of Soluble Epoxide Hydrolase with Improved Pharmacokinetic Properties-Reference-Cited by-同舟云学术

Incorporation of Piperazino Functionality into 1,3-Disubstituted Urea as the Tertiary Pharmacophore Affording Potent Inhibitors of Soluble Epoxide Hydrolase with Improved Pharmacokinetic Properties

Published:2010-11-11 Issue:23 Volume:53 Page:8376-8386
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Huang Shao-Xu¹,Li Hui-Yuan¹,Liu Jun-Yan²,Morisseau Christophe²,Hammock Bruce D.²,Long Ya-Qiu¹

Affiliation:

1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

2. Department of Entomology and University of California Davis Cancer Center, University of California, One Shields Avenue, Davis, California 95616, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101087u

Reference50 articles.

1. Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6α-oxide and certain xenobiotic alkene and arene oxides

2. Purification of Hepoxilin Epoxide Hydrolase from Rat Liver

3. EPOXIDE HYDROLASES: Mechanisms, Inhibitor Designs, and Biological Roles

4. Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

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