Synthesis, Mechanism of Action, and Antiviral Activity of a New Series of Covalent Mechanism-Based Inhibitors of S-Adenosyl-l-Homocysteine Hydrolase-Reference-Cited by-同舟云学术

Synthesis, Mechanism of Action, and Antiviral Activity of a New Series of Covalent Mechanism-Based Inhibitors of S-Adenosyl-l-Homocysteine Hydrolase

Published:2001-07-18 Issue:17 Volume:44 Page:2743-2752
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Guillerm Georges¹,Guillerm Danielle¹,Vandenplas-Witkowki Corinne¹,Rogniaux Hélène¹,Carte Nathalie¹,Leize Emmanuelle¹,Van Dorsselaer Alain¹,De Clercq Erik¹,Lambert Christine¹

Affiliation:

1. Université de Reims Champagne-Ardenne, UMR 6519, UFR Sciences, BP 1039, 51687 Reims Cedex, France, Université Louis Pasteur ECPM UMR 7507, 25, rue Becquerel F, 67087 Strasbourg Cedex 2, France, Rega Institute for Medical Research, Katholieke Universiteit of Leuven, Leuven, Belgium, and AstraZeneca - Reims, Centre de Recherches, BP 1050, Chemin de Vrilly, 51689 Reims Cedex 2, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0108350

Reference38 articles.

1. 5'-terminal cap structure in eucaryotic messenger ribonucleic acids

2. Relationship between intracellular concentration of S-adenosylhomocysteine and inhibition of vaccinia virus replication and inhibition of murine L-929 cell growth

3. Priming of influenza mRNA transcription is inhibited in CHO cells treated with the methylation inhibitor, Neplanocin A

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