1. Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey (UMDNJ) and UMDNJ Informatics Institute, Piscataway, New Jersey 08854, Department of Chemistry and Biochemistry, University of MissouriSt. Louis, St. Louis, Missouri 63121, and Department of Biochemistry and Molecular Biology, New Jersey Medical School, UMDNJ, Newark, New Jersey 07101