Preparative Chromatography Technique in the Removal of Isostructural Genotoxic Impurity in Rizatriptan: Use of Physicochemical Descriptors of Solute and Adsorbent

Author:

Maddula Srinivasula Reddy1,Kharkar Manoj1,Manudhane Kushal1,Kale Sandeep1,Bhori Abijar1,Lali Arvind1,Dubey P. K.1,Sarma K. R. Janardana1,Bhattacharya Apurba1,Bandichhor Rakeshwar1

Affiliation:

1. Center of Excellence, Research and Development, Integrated Product Development, Dr. Reddy’s Laboratories Ltd., Survey Nos. 42, 45, 46, and 54 Bachupally, Qutubullapur, Ranga Reddy District 500072, Andhra Pradesh, India, Bioprocessing Lab, Chemical Engineering Department, U. I. C. T., Mumbai - 400 019, India, and College of Engineering, J. N. T. U., Hyderabad - 500072 A.P., India

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference41 articles.

1. Regulation and Control of Genotoxic Impurities in Pharmaceuticals;2nd Annual Non-Clinical Conference of the Drug Information Association (DIA),Bethesda, Maryland, U.S.A.,November 17−18, 2005; http://www.diahome.org.

2. aRathore, A., Velayudhan, A., Eds.Scale Up and Optimization in Preparative Chromatography, Principles and Biopharmaceutical Applications, Chromatographic Science Series, Vol. 88;Mercel Dekker Inc.:New York, 2003; pp289−316.

3. bCox, G. B., Ed.Preparative Enantioselective Chromatography;Blackwell Publishing:Oxford, 2005; pp297−302.

4. Rizatriptan in the treatment of migraine

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