Identification of (R)-6-(1-(4-Cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic Acid, a Highly Potent and Selective Nonsteroidal Mineralocorticoid Receptor Antagonist-Reference-Cited by-同舟云学术

Identification of (R)-6-(1-(4-Cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic Acid, a Highly Potent and Selective Nonsteroidal Mineralocorticoid Receptor Antagonist

Published:2014-04-30 Issue:10 Volume:57 Page:4273-4288
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Casimiro-Garcia Agustin¹,Piotrowski David W.²,Ambler Catherine²,Arhancet Graciela B.³,Banker Mary Ellen²,Banks Tereece²,Boustany-Kari Carine M.²,Cai Cuiman²,Chen Xiangyang³,Eudy Rena²,Hepworth David¹,Hulford Catherine A.²,Jennings Sandra M.²,Loria Paula M.²,Meyers Marvin J.³,Petersen Donna N.²,Raheja Neil K.²,Sammons Matthew⁴,She Li²,Song Kun⁴,Vrieze Derek²,Wei Liuqing²

Affiliation:

1. Pfizer Worldwide Research and Development, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, United States

2. Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States

3. Pfizer Worldwide Medicinal Chemistry, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017, United States

4. Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500206r

Reference44 articles.

1. International Union of Pharmacology. LXV. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Glucocorticoid, Mineralocorticoid, Progesterone, and Androgen Receptors

2. The Nuclear Receptor Superfamily and Drug Discovery

3. Aldosterone and the Heart: From Basic Research to Clinical Evidence

4. Aldosterone and the Kidney

5. Mineralocorticoid Receptor Blockade But Not Steroid Withdrawal Reverses Renal Fibrosis in Deoxycorticosterone/Salt Rats

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recent advances in the synthesis of pyrazoline derivatives from chalcones as potent pharmacological agents: A comprehensive review;Results in Chemistry;2024-01

2. Research Progress in the Organic Synthesis of β,γ-Unsaturated-α-Ketoesters;Journal of Organic Chemistry Research;2024

3. Synthesis and Antiproliferative Activity of 2-Oxo-4-Cyano-1,2-Dihydropyridine-3-Carboxamides;Pharmaceutical Chemistry Journal;2023-11

4. Diverse Pharmacological Potential of different Substituted Pyrazole Derivatives;Current Organic Synthesis;2023-10-12

5. Facile Synthesis of 2-Methylnicotinonitrile through Degenerate Ring Transformation of Pyridinium Salts;The Journal of Organic Chemistry;2022-06-05