Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B through Structure-Based Drug Design-Reference-Cited by-同舟云学术

Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B through Structure-Based Drug Design

Published:2001-11-14 Issue:26 Volume:44 Page:4524-4534
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Greenspan Paul D.¹,Clark Kirk L.¹,Tommasi Ruben A.¹,Cowen Scott D.¹,McQuire Leslie W.¹,Farley David L.¹,van Duzer John H.¹,Goldberg Ronald L.¹,Zhou Huanghai¹,Du Zhengming¹,Fitt John J.¹,Coppa David E.¹,Fang Zheng¹,Macchia William¹,Zhu Lijuan¹,Capparelli Michael P.¹,Goldstein Robert¹,Wigg Andrew M.¹,Doughty John R.¹,Bohacek Regine S.¹,Knap Ania K.¹

Affiliation:

1. Arthritis and Bone Metabolism Research, Novartis Pharmaceuticals Corporation, 556 Morris Avenue, Summit, New Jersey 07901

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm010206q

Reference36 articles.

1. Lysosomal cysteine proteases: more than scavengers

2. EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN BIOLOGY

3. [42] Cathepsin G

4. Differential distribution of messenger RNAs for cathepsins B, L and S in adult rat brain: An in situ hybridization study

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