New Diarylmethylpiperazines as Potent and Selective Nonpeptidic δ Opioid Receptor Agonists with Increased In Vitro Metabolic Stability-Reference-Cited by-同舟云学术

New Diarylmethylpiperazines as Potent and Selective Nonpeptidic δ Opioid Receptor Agonists with Increased In Vitro Metabolic Stability

Published:2000-09-19 Issue:21 Volume:43 Page:3878-3894
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Plobeck Niklas¹,Delorme Daniel¹,Wei Zhong-Yong¹,Yang Hua¹,Zhou Fei¹,Schwarz Peter¹,Gawell Lars¹,Gagnon Hélène¹,Pelcman Benjamin¹,Schmidt Ralf¹,Yue Shi Yi¹,Walpole Christopher¹,Brown William¹,Zhou Edward¹,Labarre Maryse¹,Payza Kemal¹,St-Onge Stephane¹,Kamassah Augustus¹,Morin Pierre-Emmanuel¹,Projean Denis¹,Ducharme Julie¹,Roberts Edward¹

Affiliation:

1. Departments of Chemistry and Pharmacology, AstraZeneca R&D Montreal, 7171 Frederick-Banting, Saint-Laurent, Quebec, Canada H4S 1Z9

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm000228x

Reference30 articles.

1. Non-peptide δ opioid agonists and antagonists (Part II)

2. Probes for Narcotic Receptor Mediated Phenomena. 23. Synthesis, Opioid Receptor Binding, and Bioassay of the Highly Selective δ Agonist (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and Related Novel Nonpeptide δ Opioid Receptor Ligands

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