Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors-Reference-Cited by-同舟云学术

Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors

Published:2006-05-13 Issue:12 Volume:49 Page:3520-3535
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pei Zhonghua¹,Li Xiaofeng¹,Longenecker Kenton¹,von Geldern Thomas W.¹,Wiedeman Paul E.¹,Lubben Thomas H.¹,Zinker Bradley A.¹,Stewart Kent¹,Ballaron Stephen J.¹,Stashko Michael A.¹,Mika Amanda K.¹,Beno David W. A.¹,Long Michelle¹,Wells Heidi¹,Kempf-Grote Anita J.¹,Madar David J.¹,McDermott Todd S.¹,Bhagavatula Lakshmi¹,Fickes Michael G.¹,Pireh Daisy¹,Solomon Larry R.¹,Lake Marc R.¹,Edalji Rohinton¹,Fry Elizabeth H.¹,Sham Hing L.¹,Trevillyan James M.¹

Affiliation:

1. Metabolic Disease Research, Advanced Technology, Departments of Exploratory Pharmacokinetics and Pharmaceutics, and Process Chemistry, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-3500

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm051283e

Reference56 articles.

1. Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.

2. Effect of Truncated Glucagon-Like Peptide-1 [Proglucagon-(78–107) amide] on Endocrine Secretion from Pig Pancreas, Antrum, and Nonantral Stomach

3. Effects of Glucagon-Like Peptide 1 on Counterregulatory Hormone Responses, Cognitive Functions, and Insulin Secretion during Hyperinsulinemic, Stepped Hypoglycemic Clamp Experiments in Healthy Volunteers

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