Enzymatic Desymmetrization of Prochiral 2-Substituted-1,3-propanediols: A Practical Chemoenzymatic Synthesis of a Key Precursor of SCH51048, a Broad-Spectrum Orally Active Antifungal Agent-Reference-Cited by-同舟云学术

Enzymatic Desymmetrization of Prochiral 2-Substituted-1,3-propanediols: A Practical Chemoenzymatic Synthesis of a Key Precursor of SCH51048, a Broad-Spectrum Orally Active Antifungal Agent

Published:1997-10-01 Issue:22 Volume:62 Page:7736-7743
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Morgan Brian¹,Dodds David R.¹,Zaks Aleksey¹,Andrews David R.¹,Klesse Ricardo¹

Affiliation:

1. Schering-Plough Research Institute, Biotransformations Group, K-15-1/1800, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033-0539, and Chemical Process R & D, 1011 Morris Avenue, Union, New Jersey 07083

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo9709920

Reference16 articles.

1. Enantioselective synthesis of the optical isomers of broad-spectrum orally active antifungal azoles, Sch 42538 and Sch 45012

2. PPL-catalyzed enzymatic asymmetrization of a 2-substituted prochiral 1,3-diol with remote chiral functionality: Improvements toward synthesis of the eutomers of SCH 45012

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