New Antipsychotic Agents with Serotonin and Dopamine Antagonist Properties Based on a Pyrrolo[2,1-b][1,3]benzothiazepine Structure

Author:

Campiani Giuseppe1,Nacci Vito1,Bechelli Susanna1,Ciani Silvia M.1,Garofalo Antonio1,Fiorini Isabella1,Wikström Håkan1,de Boer Peter1,Liao Yi1,Tepper Pieter G.1,Cagnotto Alfredo1,Mennini Tiziana1

Affiliation:

1. Dipartimento Farmaco Chimico Tecnologico, Universita' di Siena, Banchi di Sotto, 55, 53100 Siena, Italy, Department of Medicinal Chemistry, UCF, University of Groningen, Antonius Deusinglaan, 1, NL-9713 AV Groningen, The Netherlands, and Istituto di Ricerche Farmacologiche “Mario Negri”, via Eritrea 62, 20157 Milano, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference28 articles.

1. Calne, D. B.Therapeutics and Neurology; Blackwell Scientific Publications:  Oxford, 1980; p 281.

2. Evaluation in rats of the somnogenic, pyrogenic, and central nervous system depressant effects of muramyl dipeptide

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