Potent and Selective Aminopyrimidine-Based B-Raf Inhibitors with Favorable Physicochemical and Pharmacokinetic Properties-Reference-Cited by-同舟云学术

Potent and Selective Aminopyrimidine-Based B-Raf Inhibitors with Favorable Physicochemical and Pharmacokinetic Properties

Published:2012-02-29 Issue:6 Volume:55 Page:2869-2881
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mathieu Simon¹,Gradl Stefan N.¹,Ren Li²,Wen Zhaoyang¹,Aliagas Ignacio¹,Gunzner-Toste Janet¹,Lee Wendy¹,Pulk Rebecca¹,Zhao Guiling¹,Alicke Bruno¹,Boggs Jason W.¹,Buckmelter Alex J.²,Choo Edna F.¹,Dinkel Victoria²,Gloor Susan L.²,Gould Stephen E.¹,Hansen Joshua D.²,Hastings Gregg²,Hatzivassiliou Georgia¹,Laird Ellen R.²,Moreno David²,Ran Yingqing¹,Voegtli Walter C.²,Wenglowsky Steve²,Grina Jonas²,Rudolph Joachim¹

Affiliation:

1. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080-4990, United States

2. Array BioPharma, 3200 Walnut Street, Boulder, Colorado 80301, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300016v

Reference17 articles.

1. The Raf/MEK/ERK pathway: new concepts of activation

2. Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF