1. Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, University of Guam Marine Laboratory, UOG Station, Mangilao, Guam 96923, Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, Hawaii 96813, Karmanos Cancer Center, Wayne State University, Detroit, Michigan 48201, and Department of Internal Medicine, Wayne State University, Detroit, Michigan 48201