1. Department of Chemistry and Biophysics, §Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan, United States, and ∥Michigan Center for Translational Pathology, Department of Pathology, ⊥Department of Urology, #Comprehensive Cancer Center, and ¶Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan, United States