High-Throughput Measurement of pKa Values in a Mixed-Buffer Linear pH Gradient System-Reference-Cited by-同舟云学术

High-Throughput Measurement of pKa Values in a Mixed-Buffer Linear pH Gradient System

Published:2003-01-15 Issue:4 Volume:75 Page:883-892
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Box Karl¹,Bevan Christopher¹,Comer John¹,Hill Alan¹,Allen Ruth¹,Reynolds Derek¹

Affiliation:

1. Sirius Analytical Instruments Ltd., Riverside, Forest Row Business Park, Forest Row, East Sussex, RH18 5DW, United Kingdom, Analytical and Structural Sciences Department, Medicines Research Centre, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts, SG1 2NY, United Kingdom, and REYTEK Limited, 11C Rothsay Road, Bedford, Bedfordshire, MK40 3PP, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ac020329y

Reference39 articles.

1. Comer, J.; Tam, K. Lipophilicity Profiles: Theory and Measurement. InPharmacokinetic Optimization in Drug Research: Biological,Physicochemical and Computational Strategies, E; Testa, B., van de Waterbeemd, H., Folkers, G., Guy, R., Eds.; VHCA: Zurich, 2001; pp 275−304.

2. pH-Metric log P. Part 1. Difference Plots for Determining Ion-Pair Octanol-Water Partition Coefficients of Multiprotic Substances

3. Multiwavelength spectrophotometric determination of acid dissociation constants of ionizable drugs

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