Effect of Plasma Protein Binding on in Vivo Activity and Brain Penetration of Glycine/NMDA Receptor Antagonists-Reference-Cited by-同舟云学术

Effect of Plasma Protein Binding on in Vivo Activity and Brain Penetration of Glycine/NMDA Receptor Antagonists

Published:1997-12-01 Issue:25 Volume:40 Page:4053-4068
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rowley Michael¹,Kulagowski Janusz J.¹,Watt Alan P.¹,Rathbone Denise¹,Stevenson Graeme I.¹,Carling Robert W.¹,Baker Raymond¹,Marshall George R.¹,Kemp John A.¹,Foster Alan C.¹,Grimwood Sarah¹,Hargreaves Richard¹,Hurley Catherine¹,Saywell Kay L.¹,Tricklebank Mark D.¹,Leeson Paul D.¹

Affiliation:

1. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm970417o

Reference54 articles.

1. Relationship between Lipophilic Character and Anesthetic Activity

2. Hydrophobicity and Central Nervous System Agents: On the Principle of Minimal Hydrophobicity in Drug Design

3. QSAR studies on drugs acting at the central nervous system

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