Stereoselective Synthesis of a Potent Thrombin Inhibitor by a Novel P2−P3 Lactone Ring Opening-Reference-Cited by-同舟云学术

Stereoselective Synthesis of a Potent Thrombin Inhibitor by a Novel P2−P3 Lactone Ring Opening

Published:2004-05-01 Issue:11 Volume:69 Page:3620-3627
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Nelson Todd D.¹,LeBlond Carl R.¹,Frantz Doug E.¹,Matty Louis¹,Mitten Jeffrey V.¹,Weaver Damian G.¹,Moore Jeffrey C.¹,Kim Jaehon M.¹,Boyd Russell¹,Kim Pei-Yi¹,Gbewonyo Kodzo¹,Brower Mark¹,Sturr Michael¹,McLaughlin Kathleen¹,McMasters Daniel R.¹,Kress Michael H.¹,McNamara James M.¹,Dolling Ulf H.¹

Affiliation:

1. Department of Process Research, Merck Research Laboratories, Merck & Co., 466 Devon Park Drive, Wayne, Pennsylvania 19087, Department of Bioprocess R&D, Merck Research Laboratories, Merck & Co., Rahway, New Jersey 07065, Department of Process Research, Merck Research Laboratories, Merck & Co., Rahway, New Jersey 07065, and Department of Molecular Systems, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo035794p

Reference41 articles.

1. New advances in the discovery of thrombin and factor Xa inhibitors

2. Recent advances in the status and targets of antithrombotic agents

3. Bivalirudin: A direct thrombin inhibitor

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