Structure−Activity Relationships of Orotidine-5′-Monophosphate Decarboxylase Inhibitors as Anticancer Agents-Reference-Cited by-同舟云学术

Structure−Activity Relationships of Orotidine-5′-Monophosphate Decarboxylase Inhibitors as Anticancer Agents

Published:2009-03-04 Issue:6 Volume:52 Page:1648-1658
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bello Angelica M.¹,Konforte Danijela¹,Poduch Ewa¹,Furlonger Caren¹,Wei Lianhu¹,Liu Yan¹,Lewis Melissa¹,Pai Emil F.¹,Paige Christopher J.¹,Kotra Lakshmi P.¹

Affiliation:

1. Center for Molecular Design and Preformulations and Division of Cellular and Molecular Biology, Toronto General Research Institute, Toronto General Hospital, Toronto, Ontario M5G 2C4, Canada, Department of Medical Biophysics, Ontario Cancer Institute, Princess Margaret Hospital, 620 University Avenue, Toronto, Ontario M5G 2M9, Canada, Department of Immunology, University of Toronto, Toronto, Ontario, Canada, Departments of Biochemistry and Molecular Genetics, University of Toronto, 1 King’s College...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801224t

Reference43 articles.

1. Cytotoxic Nucleoside Analogues: Different Strategies to Improve their Clinical Efficacy

2. A New Mechanism of Methotrexate Action Revealed by Target Screening with Affinity Beads

3. Computer simulations of enzyme catalysis: Finding out what has been optimized by evolution

4. Catalytic Proficiency: The Unusual Case of OMP Decarboxylase

5. Equilibrium of Formation of the 6-Carbanion of UMP, a Potential Intermediate in the Action of OMP Decarboxylase

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