Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase-Reference-Cited by-同舟云学术

Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase

Published:2010-12-03 Issue:1 Volume:54 Page:312-319
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Prime Michael E.¹,Courtney Stephen M.¹,Brookfield Frederick A.¹,Marston Richard W.¹,Walker Victoria¹,Warne Justin¹,Boyd Andrew E.¹,Kairies Norman A.²,von der Saal Wolfgang³,Limberg Anja³,Georges Guy³,Engh Richard A.²,Goller Bernhard³,Rueger Petra³,Rueth Matthias³

Affiliation:

1. Evotec (UK) Ltd., 114 Milton Park, Abingdon, OX14 4SA, U.K.

2. Max-Planck Institute for Biochemistry, Am Klopferspitz 18, 82152 Planegg, Germany

3. Roche Diagnostics GmbH, Pharma Research Penzberg, D-82372 Penzberg, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101346r

Reference24 articles.

1. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines