Unichiral 2-(2′-Pyrrolidinyl)-1,4-benzodioxanes: the 2R,2′S Diastereomer of the N-Methyl-7-hydroxy Analogue Is a Potent α4β2- and α6β2-Nicotinic Acetylcholine Receptor Partial Agonist-Reference-Cited by-同舟云学术

Unichiral 2-(2′-Pyrrolidinyl)-1,4-benzodioxanes: the 2R,2′S Diastereomer of the N-Methyl-7-hydroxy Analogue Is a Potent α4β2- and α6β2-Nicotinic Acetylcholine Receptor Partial Agonist

Published:2011-10-11 Issue:21 Volume:54 Page:7588-7601
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bolchi Cristiano¹,Gotti Cecilia²,Binda Matteo¹,Fumagalli Laura¹,Pucci Luca²,Pistillo Francesco³,Vistoli Giulio¹,Valoti Ermanno¹,Pallavicini Marco¹

Affiliation:

1. Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Università degli Studi di Milano, via Mangiagalli 25, I-20133 Milano, Italia

2. CNR, Istituto di Neuroscienze, via Vanvitelli 32, I-20129 Milano Italia

3. Neuromed IRCCS, via Atinese 18, I-86077 Isernia, Italia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200937t

Reference31 articles.

1. Central Nicotinic Receptors: Structure, Function, Ligands, and Therapeutic Potential

2. Structural and functional diversity of native brain neuronal nicotinic receptors

3. Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

4. Modeling Subtype-Selective Agonists Binding with α4β2 and α7 Nicotinic Acetylcholine Receptors: Effects of Local Binding and Long-Range Electrostatic Interactions

5. Structural differences determine the relative selectivity of nicotinic compounds for native α4β2*-, α6β2*-, α3β4*- and α7-nicotine acetylcholine receptors

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