1. Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas 72701, Department of Chemistry, National Tsing Hua University, Hsinchu 30043, Taiwan, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, Quebec H4P 2R2, Canada, Department of Internal Medicine, The Ohio State University, 480 West 9th Avenue, Columbus, Ohio 43210-1228, and Graduate Institute of Marine Biotechnology, National Taiwan Ocean University, Taiwan