Discovery of Dual VEGFR-2 and Tubulin Inhibitors with in Vivo Efficacy

Author:

Chekler Eugene L. Piatnitski1,Kiselyov Alexander S.1,Ouyang Xiaohu1,Chen Xiaoling1,Pattaropong Vatee1,Wang Ying2,Tuma M. Carolina2,Doody Jacqueline F.2

Affiliation:

1. Department of Chemistry

2. Department of Cell Biology

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference14 articles.

1. Microtubule assembly dynamics: new insights at the nanoscale

2. Microtubules as a target for anticancer drugs

3. Antiangiogenic Agents: an Update on Small Molecule VEGFR Inhibitors

4. Wedge, S. R.; Kendrew, J.; Ogilvie, D. J.; Hennequin, L. F.; Brave, S. R.; Ryan, A. J; Ashton, S. E.; Calvete, J. A.; Blakey, D. C.Combination of the VEGF receptor tyrosine kinase inhibitor ZD6474 and tubulin agent ZD6126 produces an enhanced anti-tumor response.American Association for Cancer Research, Annual Meeting, 2002; Poster 5351.

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