Structure−Activity Relationships of Antitubercular Nitroimidazoles. 1. Structural Features Associated with Aerobic and Anaerobic Activities of 4- and 5-Nitroimidazoles-Reference-Cited by-同舟云学术

Structure−Activity Relationships of Antitubercular Nitroimidazoles. 1. Structural Features Associated with Aerobic and Anaerobic Activities of 4- and 5-Nitroimidazoles

Published:2009-02-11 Issue:5 Volume:52 Page:1317-1328
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kim Pilho¹,Zhang Liang¹,Manjunatha Ujjini H.¹,Singh Ramandeep¹,Patel Sejal¹,Jiricek Jan¹,Keller Thomas H.¹,Boshoff Helena I.¹,Barry Clifton E.¹,Dowd Cynthia S.¹

Affiliation:

1. Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, and Novartis Institute for Tropical Diseases, 138670, Singapore

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801246z

Reference31 articles.

1. WHO International Fact Sheet No. 104,2007.http://www.who.int/mediacentre/factsheets/fs104/en/index.html.

2. Prospects for new antitubercular drugs

3. Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

4. Tuberculosis — metabolism and respiration in the absence of growth

5. A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

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