Improved Synthesis of the Selective Rho-Kinase Inhibitor 6-Chloro-N4-{3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl}pyrimidin-2,4-diamine-Reference-Cited by-同舟云学术

Improved Synthesis of the Selective Rho-Kinase Inhibitor 6-Chloro-N4-{3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl}pyrimidin-2,4-diamine

Published:2009-12-11 Issue:1 Volume:14 Page:168-173
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Schirok Hartmut¹,Paulsen Holger¹,Kroh Walter¹,Chen Gang¹,Gao Ping¹

Affiliation:

1. Bayer Schering Pharma AG, Medicinal Chemistry Wuppertal, 42096 Wuppertal, Germany, and Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, 200032 Shanghai, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op900260k

Reference84 articles.

1. The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

2. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

3. Rho activation at a glance

4. ROCKs: multifunctional kinases in cell behaviour

5. Rho Kinases in Cardiovascular Physiology and Pathophysiology

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