Homogenous Scavenging Resolves Low-Purification Yield/Selectivity Caused by Secondary Binding of Protein-A to Antigen-Binding Antibody Fragments
Author:
Affiliation:
1. Institut National de la Recherche Scientifique (INRS), EMT Research Center, 1650 boul. Lionel-Boulet, Varennes, J3X 1S2, Canada
Funder
Fonds de Recherche du Qu?bec - Sant?
Canada First Research Excellence Fund
Natural Sciences and Engineering Research Council of Canada
TransMedTech Institute
Publisher
American Chemical Society (ACS)
Subject
Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.9b01516
Reference41 articles.
1. Development trends for human monoclonal antibody therapeutics
2. Therapeutic antibodies for human diseases at the dawn of the twenty-first century
3. Antibodies and Genetically Engineered Related Molecules: Production and Purification
4. Redesigning Nature's Poisons to Create Anti-Tumor Reagents
5. An emerging playbook for antibody–drug conjugates: lessons from the laboratory and clinic suggest a strategy for improving efficacy and safety
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